Along with NCL and EPL, the traceless Staudinger ligation has made proteins more readily accessible targets for chemical synthesis and semisynthesis.
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Thus the majority of reports on so-called "optical biopsy" target readily accessible organs and tissues such as skin, gastrointestinal and gynecologic tracts.
First, saturation of clearance (from PK analysis) signifies the saturation of the targets when the target is readily accessible.
In this case, the target organ being readily accessible, efforts have been focusing on profiling transcript abundance in skin tissues [ 43, 44].
Internet interventions have many characteristics (automation, tailoring, readily accessible), that when co-developed with target users, have the potential to help primary care patients manage their symptoms.
Phosphatidylserine exposure is a near-universal event in apoptosis that occurs within a few hours of the apoptotic stimulus and presents an abundant target that is readily accessible on the extracellular face of the plasma membrane [ 29, 30].
To provide a readily accessible marker of peripheral Src family kinase target inhibition, we assayed sCTX.
Surprisingly, the accessibility of Ascl1 to its binding sites in neural stem/progenitor cells remains largely unchanged throughout their differentiation, as Ascl1 targets regions of both readily accessible and closed chromatin in proliferating cells.
These cells are readily accessible in humans compared to the relatively inaccessible target tissues of PPARγ ligands, namely adipose tissue and liver [ 5].
Work conducted concurrently in animal models may also allow us to better understand how changes in WBC DNA methylation in response to environmental stimuli correlate to changes in target tissues/cells that are not readily accessible, such as brain regions.
