However, the addition of GS FLX Paired End reads vastly improved the capability of 454 pyrosequencing by enabling the assembly of contigs into large scaffolds.
We found that for the reads obtained using a standard miRNA-seq protocol, the number of reads aligned to tDRs (78.81 % of reads) vastly outnumbered those aligning to miRNAs (4.43 % of reads) (Fig. 1a).
Newer technologies such as Illumina, Complete Genomics (Drmanac et al., 2010), Helicos (Harris et al., 2008), 454 Life Sciences (Margulies et al., 2005), SOLiD (McKernan et al., 2009) and Ion Torrent (Rothberg et al., 2011) provide reads at vastly lower costs for greater throughput, but at the expense of length.
Or will we be happy getting everything we read from a vastly reduced pool of presses?
Our findings are that primers designed for transcript regions of higher read coverage resulted in vastly improved detection of mRNA transcripts that were not previously detected or were not consistently detected in the same samples using conventional primers.
In recent years, correction of in silico predicted gene annotations with RNA-seq derived transcripts and read alignments has enabled vastly improved genome annotations and corrections of annotated gene structures [ 4- 6].
It is, in short, so vastly irritating to read that one feels positively itchy.
But his day to day persona is vastly different from what I had read about in the music press.
To read Lowell again in a huge gulp is a vastly unsettling but exhilarating act.
However, entropy does not directly reflect significance, as samples with vastly different levels of evidence (e.g. read coverage) may lead to similar entropy values.
