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In contrast, two new techniques being developed could read the sequence directly from one DNA molecule.
The more a DNA sequence is read, the greater the certainty that the sequencing machine read the sequence accurately.
Further speeding up the process with novel chemistry and advances in nanofabrication, the companies will develop a device that can simultaneously read the sequence of multiple genomes on a single chip.
Unlike other advanced sequencing technologies currently in use, which simultaneously read multiple copies of the same piece of DNA, thus boosting the signal, the HelioScope can read the sequence from a single molecule.
The findings were part of a continuing wave of discoveries made by means of DNA microarrays, or chips, which could quickly read the sequence of human DNA at up to 500,000 points across an individual's genome.
Most techniques require DNA molecules to be amplified, or copied many times before sequencing, but even newer methods such as those being developed by Pacific Biosciences and Oxford Nanopore can read the sequence of a single molecule, making it simpler to prepare samples and piece together the sequence.
Similar(43)
The ribosome reads the sequence of nucleic acids in the mRNA and spits out a sequence of amino acids: a protein.
Scientists now broadly agree that reading the sequence of DNA is the easy part of genome analysis; figuring out what the sequence means is the real challenge.
A device that reads the sequence of DNA using semiconductor technology could bring the power of sequencing to a much broader swath of the science world.
Like other new sequencing technologies, Complete Genomics' process reads the sequence of very short pieces of DNA, which then must be computationally synthesized to create a whole genome.
Experts say single-molecule sequencing, which reads the sequence of a single fragment of DNA, will ultimately simplify and speed the sequencing process, which could in turn enable the advance of personalized medicine.
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