The strapline read: "Supporting Zac Goldsmith in the Richmond Park constituency".
We further filtered the annotated events containing no less than 10 reads supporting inclusion and 1 read supporting exclusion.
Participants were encouraged to read supporting materials prepared prior to the meeting (in consultation with presenters) in order to enhance their in-class experience and maximize the benefits from the presentations and the class discussion.
We accommodate this influence of | P P | expected fetal haplotypes instead of regular two as follows: (2) r ′ = | P P | · r / 2 | P P | · r / 2 + (1 − r ) Then for each nucleotide x we compute the probability p x of observing a read supporting x.
Likewise, any CpG sites overlapped by reads carrying alternative alleles (excluding those expected from bisulfite conversion) were excluded, and all CpG sites had to be covered by at least one read supporting the presence of a cytosine at the corresponding position.
Default settings were used (minimum read mapping/base quality to consider a read/base for variant calling 10; ≥ 1 read supporting variant must have mapping quality ≥ 20; ≥ 4 reads per pool; contingency table threshold p = 10-3; quality values based p-value threshold 10-5).
