Sentence examples for read proportions from inspiring English sources

Comparison of mutant read proportions for substitutions at each nucleotide position across all samples.

These five samples included the samples with the four highest scoring read proportions from PathoScope.

Considering the deviant read proportions or frequencies associated with each polymorphism type, we see comparable trends among significant polymorphisms.

By contrast, germline variants have read proportions of either 1 (for homozygous variants) or ~0.5 (for heterozygous variants) in regions where the tumor genome is diploid.

Conversely, genomic copy number gains may sometimes cause somatic mutation to have read proportions greater than 0.5, so this two-step approach sometimes incorrectly excludes somatic mutations.

For these genomes, the Unified Genotyper was run in haploid mode, and so read proportions were analyzed in place of called heterozygous sites, and specifically the proportion of sites in which less than 75% of reads supported the consensus base.

In the present study we have also noted that let-7 family members were highly expressed across all libraries and conclude that this is indeed a true reflection of their relative abundance as the mRNA expression levels of some of their known gene targets, the RAS family [29] and HMGA2 [30], show an inverse correlation with read proportion and relative gene expression (data not shown).

For each position, we summed the deviant reads and computed the deviant read proportion (by dividing the sum of deviant reads by the coverage; for example, if a genome position is spanned by 100 reads of which 10 contain mismatches, then the deviant read proportion will be 10/100 = 10%).

Before correcting for background effects, which may be caused by machine error, the deviant read proportion constitutes a noisy estimate of polymorphism frequency.

In our first and simplest filter, we excluded from analysis all genome positions with a deviant read proportion less than the maximum observed proportion in time point zero samples (≈1.51%).

However, there was one discordant sample with a very low M. catarrhalis read proportion (0.02) that scored very high with respect to the gene expression signature (P003 in Fig.  4c).