This particular adenine is the most conformationally flexible residue in the PTC and was found to be strongly reactive to SHAPE 2′ OH modification in E. coli and S. cerevisiae in the absence of tRNA in purified ribosomes.
Such networks, preferentially located in the amorphous phase, were found to be more reactive to chemical and probably thermal modifications.
The active sites of CifPl and CifBp are shown to contain reactive cysteines, which are accessible to modification by a thiol-reactive compound.
Examination of proteins associated with eigenprotein #1 profile showed enrichment of proteins related to modification of reactive oxygen species.
Particularly the polyunsaturated fatty acid side chains of membrane phospholipids are highly susceptible to modification by reactive oxygen intermediates, which potentially yields an enormous array of distinct lipid oxidation products with diverse biological effects (Leitinger, 2003; Berliner & Watson, 2005; Bochkov et al, 2010; Lee et al, 2012).
The ParM construct contains two exposed cysteine residues (Cys and Cys) that are accessible to modification with thiol-reactive iodoacetamide probes.
As a result, a reactive bitumen modification mechanism, involving a set of three chemical reactions, has been proposed.
TRPV1 and/or TRPA1 are prime candidate receptors, as they are expressed in nociceptors, are blocked by RR, and are known to be sensitive to reactive chemicals via covalent modification of cysteine residues [26] [28].
A first global mechanism may be oxidation; alcohol induces the general reactive oxidative modification of proteins.
We present a mathematical model able to describe the complete molecular weight distributions of polyethylene during reactive modification by organic peroxides.
Its proper assembly is thought to be important to correctly position the Neh2 domain for ubiquitination and may be disrupted under conditions of cellular stress by modifications to the reactive cysteine residues in Keap1 [38], [44], [44].
