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During the 2010 World Cup I wrote a piece in which I pointed out that Germany were a reactive side who counterattacked brilliantly.
They are more effective as a reactive side and that, perhaps, should be a warning to future, more vaunted, opponents not to underestimate them.
Bayern accepted over the course of the semi-final that they would be the more reactive side, sitting deep and springing rapid counterattacks, something they could do because of the pace through the side and the capacity of Bastian Schweinsteiger, Dante and, especially, Javi Martínez to release long passes.
The reactive side's job is conventional fighting, though it will have fewer tanks than formerly.
Conventionally, these polymers are attached to random locations on the protein surfaces through the modification of the reactive side chains of amino acid residues such as lysine and cysteine.
The decreases in GP as the content of monomers increases could be attributed to the less reactive side on the GG as its content remains constant, and hence, there are more molecules of DMAPMAm and AMPS than GG and this could lead to the formation of homopolymer and hence low yield.
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Look at last year's Copa América, where the first knockout round saw the four reactive sides (Venezuela, Peru, Uruguay and Paraguay) progress past the four sides who wanted to play good football (Brazil, Argentina, Chile and Colombia).
Biodegradable films and sponges of poly(depsipeptide-co-lactide)s with two reactive side-chain groups, poly[(Glc Asp -co-LA] and poly[(Glc Asp -co-LA], were prepared with entrapped Glc Asp -co-LA (bFGF, EGF, and NGF) or models for these growth factors (lysozyme, insulin and lactoferrin) based on their physicochemical similarities.
Previously, we reported the synthesis of biodegradable copolymers of lactide and depsipeptide, poly(lactide- co-depsipeptide), with reactive side-chain groups such as COOH, NH2, OH, and SH by ring-opening copolymerization of lactide with cyclodepsipeptides consisting of the corresponding amino acids and glycolic acid (Glc) [ 23– 26].
Interestingly, it has been reported in a pre-clinical model that αCTLA-4 and α4-1BB each reduced the auto-reactive side effects of the other [10].
As outlined in Figure 1A, we reasoned this task could be achieved via (a) a chemoselective reaction between a cysteine and a ribosomally incorporated unnatural amino acid bearing a cysteine-reactive side-chain group and (b) spontaneous release of the macrocyclic peptide by means of an intein-based protein splicing element.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com