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Time-resolved structures of yeast proteasome:PR-957 complexes indicate that ligand docking to the active site occurs only via the reactive head group and the P1 side chain.
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For that purpose, four amphiphilic molecules were designed to insert into bilayers while presenting a reactive functional head.
In this manner, a dioleylglycero-ethoxy-ethoxy-ethoxy-ethanamine (DOG-PEG4-NH2) was chosen as a common platform while the reactive amine head was converted into several electrophilic functions.
When you get clearer about your own stuff -- your reactive tendencies, head trips, projections, and desires, you can take responsibility for your behavior.
His eyes were open, pupils were reactive, and his head was normocephalic and atraumatic.
While with your hands you can be more reactive, when your head is squashed between someone's thighs it is impossible to really control what's going on and your partner's reactions – managing to do both at the same time is superhuman.
Interestingly, in the optic nerve head, reactive astrocytes express many new extracellular matrix proteins such as laminin, tenascin C, elastin, and proteoglycans [7], [8], [29].
To decipher the regulatory elements controlling astrocyte-mediated neurotoxicity in glaucoma, we conducted a systems-level functional analysis of gene expression, proteomic and genetic data associated with reactive optic nerve head astrocytes (ONHAs).
On the other hand, touching of the hind limbs, which may occur during milking, elicited kicking or restlessness in scrapie-affected goats, even on repeated examinations and in the vast majority of animals that were not considered to be over-reactive when the head was touched (data not shown).
The total immunoglobulin (Ig) and phagocyte activity were lower while serum alternative complement and lysozyme activities, and the production of reactive oxygen species by head kidney leucocytes were higher in fish fed the higher amount of vitamin E.
"We've been forced into a completely reactive mode," says CASS head Lewis Ball.
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