DIBI has a lophine skeleton carrying an iodide atom acting as fluorophore and reactive center, respectively.
DIB-ET has a lophine skeleton carrying an alkyne acting as fluorophore and reactive center, respectively.
T. Ohta, "On hypervariability at the reactive center of proteolytic enzymes and their inhibitors," Journal of Molecular Evolution 39 (1994): 614-619.
A label remote from the reactive center is often also required to follow the course of a reaction or the location of the cofactor.
Enediynes possess a common reactive center along with a chemical functionality that can trigger a cascade of events to form a highly reactive aryl-diradical.
As the reactive center of the OEC has been shown to contain an oxo-Mn4Ca cluster, exact structural models necessitate a tetranuclear Mn core.
The enhanced photocatalytic activity was mainly attributed to the increased amounts of O2− reactive species and surface Ti3+ reactive center on silver-loaded TiO2 photocatalyst.
Rapid amplification of the cDNA ends (RACE) and primers designed based on a conserved serpin amino acid motif (NAVYFKG) were used to clone a cDNA with high similarity in the reactive center loop (RCL) to representative serpin, heparin cofactor II.
Serpin polymerization, which causes a range of diseases such as emphysema, thrombosis and dementia, occurs through a process in which the reactive center loop residues of one serpin molecule insert into the A β-sheet of another.
By combining interactions of both an exposed reactive center loop and exosites outside this loop with the active site and complementary exosites on the target protease, serpins can achieve remarkable specificity.
Here, we show that insertion of an exogenous peptide having a sequence corresponding to the first strand of β-sheet C (s1C) is facilitated in Mmalton α1AT, suggesting that the endogenous s1C and reactive center loop are easily released from β-sheet C, thus promoting latency conversion.
