Sentence examples for reactivation strategy from inspiring English sources
CRISPR-mediated gene activation represents a novel system which provides enhanced efficiency and specificity in a targeted latency reactivation strategy and represents a promising approach to a "functional cure" of HIV/AIDS.
Test work using hydration in a similar manner to a reactivation strategy has been shown to be ineffective for sulphide destruction when used directly with char from a topping cycle gasifier.
Prior focus of p53 reactivation strategy has been on targeting the Mdm2 p53 and/or MdmX p53 interface.
In combination with anti-retroviral therapy (ART), the reactivation strategy might enable the eradication of the virus in patients.
An effective reactivation strategy would therefore aim at tipping this balance by either suppressing pro-inflammatory responses, or promoting anti-inflammatory responses, or both.
A prime example of such drug concentration (dose) constraints involves proviral reactivation strategies for curing HIV.
Best results were obtained with 30% (v/v) ethyleneglycol (EG) in both reactivation strategies.
By turning on expression of latent HIV proviruses, reactivation strategies could contribute to the eradication HIV infection.
This impacts reactivation strategies such as histone deacetylase inhibitor (HDACi), which are 10-fold more active in transformed cells compared with non-transformed cells.
This review will be focused on reactivation strategies describing compounds that are being considered for the eradication of HIV infection by turning on expression of latent HIV proviruses with emphasis on agents that are currently being or soon to be tested in clinical trials.
This section also includes a review on the elimination of the latent HIV reservoir by reactivation strategies (Rasmussen, p. 790), and a number of commentaries discussing the identification of biomarkers in cancer vaccine development (Harrop, p. 800), mucosal Lactobacillus-vectored vaccines (Yu, p. 805), and short peptides as immunomodulators (Dong, p. 808).
