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In IAI, viral reactivation rates, secondary (re-) infection rates, and mortality is increased.
A subclone selected for lower reactivation rates proved to have an abnormal, integrated genome [6].
The reactivation rates of V146H/L363E hCE1 after sarin and soman inhibition were 5- and 20-fold faster, respectively, than the wt enzyme.
The diversity of study designs and the heterogeneity in individual HSV-2 reactivation rates [12] further complicate estimations of some parameters [24].
Indeed, HIV-induced depletion of Mtb-specific CD4 T cells in the granuloma, and subsequent disruption of cellular architecture critical [27] for bacterial containment, have been hypothesized as factors contributing to increased reactivation rates in co-infected humans [9], [35].
The S11 tumour cell line has been used to define some aspects of MuHV-4 latency [5] but again shows high reactivation rates and offers no way to compare recombinant viruses with the wild-type or uninfected controls.
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They found that NiFe2O4 system needs lower reactivation rate (conducted after the water-splitting reaction) compared to Ni0.5Mn0.5Fe2O4 system.
We present here the Y124H/Y72D mutant of human acetylcholinesterase; its spontaneous reactivation rate after V-agent inhibition is increased up to 110 fold.
A new reactivation rate constant, Kmax, was introduced into the logistic model to simulate the reactivation data, which showed positive relationship with the maximum survival ratio and was more reasonable to interpret the results of photoreactivation and dark repair.
In our previous study, the DPE controlled radical polymerization with constant molecular weight throughout the polymerization was caused by the intrinsically low reactivation rate constant (k2) of DPE capped dormant chains.
Apparent reactivation rate was higher in the case of direct incubation in reactivation media, best results being obtained when using 100 mM 7-ADCA and 30% (v/v) EG, with an increase with respect to the control (fully aqueous medium with no modulator) from 0.309 h−1 to 1.129 h−1, while for unfolding refolding strategy increase was only from 0.124 h−1 to 0.384 h−1.
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