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Second, the CA1 ensemble reactivation patterns were mostly derived from the intensity-invariant cell population.
This is consistent with our MDA analysis that the intensity-modulated cell population contributes to the process of encoding, but is inactive during re-emergence of reactivation patterns.
Natural history studies have also shown small alterations in reactivation patterns of individuals over 10 years, and drug treatment trials involving persons treated for 6 10 years have shown the virus persists [77].
Anatomical outcomes include the regression patterns of new vessels at 12 weeks and the regression and reactivation patterns at 52 weeks.
10.7554/eLife.00312.013 Figure 5. Neither home cage activity nor emotional value of context has a significant impact on reactivation patterns in CA1 and DG.
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Thus, HC activity does not seem to have a dramatic impact on the population reactivation pattern in CA1 and the DG.
The data are presented in Figure 5. Results of this experiment are similar to that of the contextual fear conditioning experiment, suggesting that changes in the emotional value of the context do not significantly influence the reactivation pattern of neurons in CA1 and the DG. 7. The cell quantification methods are poorly described.
Reactivations patterns of episodic experiences revealed by MDA/Sliding-window method were further corroborated by both pair-wise cross-correlations, and explained variance.
Reactivation of waking patterns is suggested to be largely confined to SWR periods (Buzsaki, 1989) during which the synchronized firing of CA1 pyramidal cells facilitates the transfer of reactivated patterns to other cortical areas (Chrobak & Buzsaki, 1994).
Sleep consolidates spatial memory through reactivation of patterns of neural activity associated with spatial navigation.
This is indicative of the reverse initiation of cells firing during eSWRs, and not the reverse reactivation of complete patterns.
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