We next investigated whether factors identified in the GFP reactivation screen function in epigenetic silencing of cellular genes.
It should be noted that the rapid reactivation of effector function of these in vitro generated "central memory" cells, supports the contention that they have acquired the properties of memory cells, as restimulation of primary effectors results in activation induced cell death [31], [32].
10.7554/eLife.05871.009 Figure 7. Effects of Nrg1 reactivation on cardiac function.
The first aberrancy was the elevated basal or cytokine-stimulated level of phosphorylated ERK (Fig. 4B and 4G, right panel) and the second was the reactivation of LIFR function (Fig. 4D and 4H, right panel).
We demonstrate that such interaction results in the abrogation of mortalin-p53 interaction leading to nuclear translocation and transcriptional reactivation of p53 function that results in an induction of senescence in cancer cells.
Upregulation and reactivation of HER3 function as escape mechanisms from EGFR inhibition and may play a role in tumor resistance to EGFR-targeting tyrosine kinase inhibitors (Schoeberl et al., 2010, Xia et al., 2005, Sergina et al., 2007, Wheeler et al., 2008, Baselga and Swain, 2009, Garrett et al., 2011).
Can telomerase reactivation serve other functions beyond re-establishing telomere maintenance?
Transcriptomic responses to the addition of either N or P suggest a concerted program leading to the reactivation of chloroplast functions.
Inhibition of autophagy impaired Zn II -induced reactivation of wtp53 functions, including binding to target promoters and transactivation of target genes, rather enhancing the dominant-negative effects of p53H175.
