These dreams are reactivating memories from the previous day to see which ones need to be consolidated.
Reactivation is thought to trigger a consolidation-like process because reactivated memory and newly acquired memory have similar time courses of susceptibility to protein synthesis inhibition: they are intact in the short term but impaired in the long term when a protein synthesis inhibitor is administered either upon retrieval or upon de novo learning [ 40].
Consistent with the results shown in Figure 1A, the VEH and ANI groups displayed enhancement and disruption, respectively, of the reactivated memory at PR-LTM, although both groups displayed comparable crossover latency at Reactivation compared to the VEH and ANI groups, respectively, in Figure 1A.
In contrast, re-exposure of the VEH and ANI groups to the light compartment for 3 min resulted in the enhancement and disruption, respectively, of the reactivated memory compared to the controls (0 min (no) re-exposure groups in Reactivation and control group re-exposed 24 hr after training, respectively).
A reactivated memory relies on de novo protein synthesis to be faithfully reconsolidated and restored.
Likewise, when anisomycin and cycloheximide were administered immediately after additional cocaine and saline conditioning trials, the reactivated memory engendered by those extra training trials was also diminished.
Distinct in vivo kinetic patterns were noted for resting memory and reactivated memory OT-I cells.
Thus reactivated memory T cells control tumor growth in an antigen-specific fashion.
In contrast, reactivated memory cells were nearly undetectable (0.04±0.004×106 in the spleen) at this time point (1 day post-transfer).
The use of ex vivo reactivated memory T cells allows the T cells to expand in vivo, enter and eradicate the tumor, thereby overcoming the problem of needing to reactivate the memory T cells within the tumor.
