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The same approach can be exploited in MS in order to reactivate immune response key factors poisoned by DNA methylation.
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Numerous reports have suggested that the therapeutic vaccination did prime or reactivate immune responses, which may be regarded as more antiviral including γIFN-producing CD4+ T-helper cells and cytotoxic T lymphocytes.
In a subset of patients, subsequent muscle damage from a variety of potential causes (such as viral infection, trauma, toxin exposure) may lead to muscle damage and regeneration, and may reactivate immune responses previously generated in the initial anti-tumor response.
Importantly, successful chemotherapies and radiotherapies that prolong overall survival by years or decades (instead of weeks and months) and that act well beyond the discontinuation of the treatment generally act by reactivating the immune response against neoplastic cells, hence restoring a state of immunosurveillance [ 2– 4].
More importantly, strategies that disrupt the cancer stem cell/epithelial-mesenchymal transition-dependent signals and reactivate antitumor immune responses would bring new hope for complete elimination of all cell compartments in endometrial cancer.
These persistent or reactivated innate immune responses might be factors that act to prevent immunosuppression mediated graft acceptance, or alternatively are a consequence of other factors that initiate the rejection.
An understanding of these HCV-host interactions could lead to more effective therapies for HCV designed to reactivate the host immune response following HCV infection.
This virus stimulates polyclonal lymphocyte expansion and persists within B lymphocytes for the host's life, inhibited from reactivating by the immune response.
Retreatment with ipilimumab may result in the expansion of T-cell clones specific for the new antigen repertoire, thus reactivating the antitumour immune response.
These data indicate that in addition to direct tumor cell killing, new targeted therapy might be also designed to reactivate the body's immune response against tumor cells.
A low grade ongoing immune response against reactivated viruses is a hypothesis of CFS morbidity [ 41].
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