Sentence examples for reactivate expression from inspiring English sources

The best evidence was the ability of TG-resistant cells to reactivate expression and restore functional HPRT activity, which was evident by growth of the cells in AzHx media.

These demethylating agents have been shown to reactivate expression of numerous methylation-silenced genes.

Common to all Burkitt lymphomas, endemic or sporadic, are distinctive chromosomal translocations that reactivate expression of the c-myc protooncogene and comprise the primary oncogenic mechanism.

To extend the knowledge of factors involved in RdDM and related RdTGS, we performed a screen for ethyl methanesulfonate (EMS -induced nrd mutants that rEMS -inducedpressionrdf a silenced reporter gene, according to the strategy outlined by Page and Grossniklaus.

This loss of expression was found to be due to aberrant nuclear factor-kappa B (NF-κB) binding to its promoter, and, critically, both DNMT inhibitors and HDAC inhibitors (HDACis) could reactivate expression of miR-146a and improve LPS-induced inflammatory responses in macrophages isolated from aged mice [ 47].

Lastly, we note that the identification of gene silencing in cancer in association with CpG island methylation has led to the discovery of 5-azacytidine as a drug able to reactivate expression of such genes and to the use of 5-azacytidine for cancer treatment.

However, BS modified DNA sequencing showed that promoter methylation could not fully explain Clusterin basal and reactivated expression.

Importantly, however, after only 5 days EWS-FLI1 reactivated expression of 81 hNCSC-associated genes and inhibited expression of 126 hNC-MSC-associated genes (Table S3A).

To distinguish these possibilities, we isolated subclones from cells with silenced PTRE-HPRT that spontaneously reactivated expression and used selection for HPRT to maintain the reactivated state for at least one month (∼50 cell divisions).

Although inhibiting DNA methylation and histone deacetylation usually reactivates expression of silenced alleles [38], [39], such renewed expression is often unstable and quickly re-silences at a high frequency, possibly as a consequence of retention of some repressive histone modifications [29], [30].

Exposure to AZA reactivated expression in MAK-I and AK31, consistent with methylation-dependent silencing.