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First, any differences in the rates between the wild-type and mutant Grxs at high substrate concentrations can be explained solely by differences in the rate constants for GSH oxidation (k2. GSH vs. k2') in the two reaction schema.
To avoid the vast expansion of parameters to be optimized, in this situation we model the particularly complicated allosteric regulation for phosphofructokinase (pfkA) via non-integral reaction orders, thereby breaking from the pure elementary reaction schema, but maintaining the type of bimolecular reactions.
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However, it should be mentioned that REACTOME only provides the reactions schema but not the kinetic parameters for quantitative model development (18).
Calculations for laser light power and geometrical dimensions, determination of total number of photodetectors and the reaction time, a schema and a photograph of the system are given.
However, the consolidation contrast we reported in our manuscript equated runs for differences in retrieval performance, confidence, as well as reaction times (updated Results, Schema consolidation).
The discovery of the mechanism of protein synthesis involved the instantiation of an abstract schema for chemical reactions: reactant1 + reactant2 = product.
Indeed, the most widely-used classification of chemical reactions (the enzyme commission (EC) schema) is neither quantitative nor based on existing data.
The main schema for classifying biochemical reactions (EC) is very valuable for nomenclature purposes, but in many cases it is not clearly reflected at the molecular level.
DOI: http://dx.doi.org/10.7554/eLife.09668.006 Similarly, reaction times (RTs) and retrieval confidence between schema conditions only differed during the first run of day 1.
In addition, Hreed includes several data annotation schema such as InChI, InChIKey, reaction key, MIRIAM registry and Open ontology to ensure integrity of the propagated data.
Each database often has its own representation and set of ID numbers for identifying components like compounds and reactions, in addition to its own organization schema, suited specifically for the intended purposes of the database.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com