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Note that links in the metabolites-only network are directed in accordance with underlying reaction directions, whether these are reversible or not.
With this set of recombinant enzymes we have checked the relative inhibition of different reaction directions by 15-substituted estrogens [24] and a 16β-substituted estrogen [35] (for structures see Figure 1).
We also modified reaction directions as suggested by the gap-filler and supported by literature research.
Next, these building blocks are assembled into pathways of a specified length, taking reaction directions into account.
Reaction directions and reversibilities were assigned in accordance with the pathways and enzymes tables of the database.
Since we cannot infer reaction directions due to the way we constructed the MetaCyc network, inferred pathways are displayed as undirected graphs.
Similar(48)
They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction.
However, details of the role of H6PDH in their metabolism and their in vivo regulation remained unclear, and the reaction direction of the metabolism of these compounds has not been assessed.
The reaction direction of 11β-HSD1 is crucial with respect to its potential as a target for treatment of metabolic diseases, where a decrease of glucocorticoid reactivation, especially in adipose tissue, is thought to be beneficial [15], [39].
The reaction is annotated with the reaction direction and if it is reversible or not.
Reaction direction information was extracted from the pathway KGML file provided by KEGG.
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