The system can produce sufficient output to reach threshold for those with as much as 60 dBHL of hearing impairment for up to 8 kHz in 86% of the study population, and up to 11.2 kHz in 50% of the population.
Perhaps the lower potassium channel density and higher local input resistance in the distal dendrites allows the excitatory inputs to reach threshold for the TTX-R sodium channels.
Perhaps blocking this tonic excitation hyperpolarizes the SBACs so that that the light-evoked synaptic potentials fail to reach threshold for synaptic release, thereby blocking forward transmission of the directional signal from the SBAC to the DSGC.
Among 46 probesets interrogating the 27 known genes in the region, 26 probsets (14 genes) reached threshold for expression detection in WT samples.
(A ) ΔCT values (cycles to reach threshold for Gfra1 minus cycles to reach threshold for Gapdh, a housekeeping gene) are not significantly different between control and mutant DRGs at E13.5, E15.5, or E18.5, suggesting that transcription of Gfra1 is not changed in Gfra2 mutants.
For the auditory four-item temporal order task, however, the maximum SOA was insufficient to reach threshold for 41 subjects, 20 of whom were older adults, 15 middle-aged adults, and 6 young adults.
In this case, if INa blockade enhances Ca2+ efflux via NCX, then SR load may reach threshold for spark and wave release less frequently since the SR Ca2+-ATPase would have more competition for Ca2+ ions in the fuzzy space.
These EPSPs could be of sufficient magnitude to reach threshold for firing, suggesting that indirect presynaptic effects of leptin on DMH neurons can contribute to leptin-induced increases in neuronal excitability.
These memory-related changes in the hippocampal system might reflect a compensatory effort to overcome preclinical neural dysfunction caused by early pathological changes which do not reach threshold for behavioural expression.
We expand on this finding and show that elevated depressive symptoms that do not reach threshold for major depression are also associated with reluctance to discuss self-care information.
