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However, the absolute risk of stages 4-5 CKD in this population was low, with ∼1% of participants in our study reaching this end point.
31 Moreover, with a margin of more than 17% over placebo in reaching this end point and a NNT of 6, the benefit of acotiamide is well above the minimal range of efficacy that was proposed to be clinically relevant by a group of experts.
More specifically, eCROPS-CA first sets an ultimate goal of effective, low cost and sustainable interventions against common cancers and then identifies key success factors for reaching this end, devices necessary intervention components satisfying all these factors, and finally forms a practical whole.
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He then ruffed a heart and ruffed a club, reaching this ending.
The defense cashed a diamond winner and led a club, reaching this ending when South took his ace: When South led his club 10, the defense was helpless.
He won with the ace, and played six trumps, reaching this ending: When the last heart was led, West was in trouble.
The declarer cashed his four diamond tricks and a top spade, reaching this ending: On the spade king, West reluctantly gave up a club.
He cashed the club ace and ruffed the club queen, reaching this ending: The declarer had missed his chance to lead a diamond from dummy earlier, but still survived.
A weight loss exceeding 25% in all infected mice was used as the experimental end-point, and mice reaching this end-point were euthanized according to IACUC guidelines.
The CCC said that, to reach this end target, carbon should be cut by 60% by 2030.
Declarer ran his trumps to reach this end position: On the final heart dummy threw a club, but East did not have a card to spare.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com