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Toxicities reaching grades III IV were diarrhea, mucositis, haematological and liver toxicity, proteinuria, asthenia, emesis, pain, and colic (Table 3).
The results from our study have shown that bevacizumab+FOLFIRI combination has a good safety profile, with mostly haematologic toxicity, diarrhea, mucositis, asthenia, haemorrhages, and emesis, and, in most cases in grades I II and only reaching grades III IV in between 1.1% and 9.5%.
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The only non-haematological toxicity reaching grade III was nausea/vomiting.
Mucositis occurred in 46% of cycles but was generally moderate, reaching grade 3 or 4 in only 19 cycles (10%).
Severe AEs occurred rarely, mostly reaching grade 3 at worst, and were properly managed with dose adjustments.
Neurosensory toxicity occurred in 86% of patients, but was of mild to moderate, only reaching grade 3 in one patient.
The leucocyte and platelet counts were reduced by about 20-35%, without reaching grade greater than or equal to 2 toxicity.
Diarrhoea was the major treatment toxicity reaching grade 3/4 in 93% patients, and was often accompanied with abdominal pain (33% of patients; Table 2).
Only one patient had severe neutropenia, reaching grade 4, with the onset and nadir of the event on day 18, and lasting 3 days.
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