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The selection and analysis of the studies was conducted by only two researchers reaching concordance after discussion in all cases but still leaving room for a possible bias.
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Both assessments of EGFR expression were scored blindly by two independent observers, who reached concordance for scoring in >80% of the cases.
The purpose of this was not to reach concordance but rather to introduce different viewpoints regarding coding and interpretation of the data and to refine the coding and analysis [ 38].
18F-FDOPA (6-[18F]-L-fluoro-L-3,4-dihydroxyphenylalanine -based PET/CT has shown sensitivity profiles close to 95% in diagnosing PCCs and abdominal paragangliomas, reaching 100% concordance with MRI for the detection of PCCs [90].
Seven out of the 11 laboratories (63 %), perfectly typed more than 90% of isolates, 3 scored between 80-90% and a single center was under 80% reaching 51% concordance only.
The analysis reached good concordance between the two researchers and did not show disagreement.
In contrast, the gene expression profiles reach good concordance for the survival samples according to the extended cutoff.
For the Yoruban sample we observed a good SNP overlap (15/15) and reached a concordance of 14/15 through visual inspection in IGV.
Verification was done using PCR, RFLP and sequencing (figure 4) reaching 92% concordance.
When negative or contaminated sTA were omitted concordance reached 78% (in order to consider the value of sTA to target therapy).
The relationship was fitted to a parabolic model and the significant fitting (R 2 = 0.4844, p < 0.0001) indicated that the concordance reached a peak at a genomic GC content of around 56.7%.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com