Hence, the combined HM-PCR/MR-SNuPE assay reaches sensitivities close to the theoretical optimum.
This method is also highly sensitive and proteins can be identified in femtomole quantities and reaching sensitivity up to zeptomole (10−21 M) amounts [28], [29].
The results show that all three methods yield satisfactory results, reaching sensitivity and specificity values of greater than 70% or 80%, respectively.
For the analysis of theses pesticides in real water samples a pre-treatment step consisting of solid phase extraction (SPE) was conducted in order to reach sensitivity levels below the legal maximum concentration permitted.
Both algorithms reach sensitivity of more than 65% and coverage of more than 90%.
The EMR model, on the other hand, reached sensitivity of 0.28 (95% CIs: 0.16-0.41) athehe same specificity.
Many articles published between 1996 and 1997 suggested that F-FDG-PET could be accurate in detecting axillary nodal metastases, reaching sensitivity values in the range 79 to 100% and specificity values ranging from 66 to 100% [ 44, 55- 57].
Basiye et al. [ 66] and Mugasa et al. [ 67] have applied NASBA-OC to diagnostic assays development, based on L. donovani RNA detection, reaching sensitivity of 79.80 93.30%% (respectively) and specificity of 100%% (both).
In a collaborative trial, Leimanis et al. [ 12] applied microarrays for the detection of preamplified multiplex PCR products of GMO samples (9 GMOs, 5 plant species and 3 elements) with biotinylated primers, reaching sensitivity down to 0.1%.
There are a number of molecular techniques, especially those based on PCR technology, that are reaching sensitivity levels in the range required (1 in 10 cells) for the study of induced mutations (Morlan et al., 2009).
