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Taken together, the data with dCas9 tracrRNA crHyb confirm the reduced binding affinity for target DNA and suggest that, in concordance with the detected in vitro cleavage activity, it can reach the active conformation required for cleavage but that this state has reduced stability, in agreement with the reduced cleavage activity in cells (Fig. 5).
Their average size was 90 nm, which means that Cu NPs had surface characteristics such as high specific surface, high activity surface reaction, and effective transferring channels for analyte molecules to reach the active site, which helped to improve the sensitivity of the electrode.
Both substrate and inhibitors use this channel to reach the active site.
The logarithm of partition coefficient defined for a drug molecule relates to the partition coefficient, which allows the optimum solubility characteristics to reach the active site.
The logarithm of partition coefficient calculated for the designed inhibitors suggests that inhibitors would possibly reach the active site in sufficient concentration like in the case of SCH28080.
The presynaptic tests that showed a difference had to do with measuring the rate of calcium influx into the active zone and the number of channels through which that calcium reaches the active zone.
The reaction rates of the catalyst are also limited by how fast oxygen can move through the material to reach the active sites; this needs to be improved for the catalyst to work in fuel cells.
The substrate, ribulose bisphosphate, then reacts with these to form an enediol inter-mediate, which engages with either another CO2 or an O2 molecule, either of which must diffuse down a solvent channel to reach the active site.
In conditions where the accumulation step is diffusion-controlled, the current sampled during the detection step constitutes an indirect measurement of the speed at which the probe is reaching the active centers in the porous hybrid structure.
