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In the present study significantly more dogs sampled at day 120-150 post vaccination reached approved test results than dogs sampled at day 151-180 (Tables 1, 2; Figure 1).
There were 3,571 dogs vaccinated using vaccine A, and 3,218 dogs vaccinated using vaccine B. In the univariable analysis it was shown that dogs vaccinated with vaccine B more often reached approved antibody titres than dogs vaccinated with vaccine A (P < 0.001).
Moreover, significantly more dogs reached approved test results if antibody titres were checked at day 120-150 after vaccination compared to if they were checked at day 151-180 (P < 0.004), and two immunizations significantly increased the number of dogs reaching approved test results (P < 0.001).
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Two vaccinations increased the numbers of dogs reaching approved test results in the present study (Table 1, Figure 1).
Medium-large and large-very large pure-bred dogs had less success reaching approved test results compared to very small-small pure-bred dogs vaccinated once.
Dogs < 6 month and ≥ 5 years more often had less success in reaching approved test result compared with dogs between 6 months < 5 years of age (P < 0.05).
Breed size and breed was also significantly associated with approved test result in the univariable analysis; smaller dogs and dogs of mixed breed were more likely to reach approved test results compared with larger dogs and pure-bred dogs (P < 0.05).
The University of Caen Institutional Review Board (POSOVIR) and the University of California, San Francisco Committee on Human Subjects Research (REACH) approved all study procedures.
Pig no. 5 was scanned 14 days after inoculation in an attempt to study more chronic infections, but this extended infection period was difficult to pursue because the pigs reached the approved humane endpoint bBody weight was changed from approx 40 to 20 kg as part of the refinement of the porcine osteomyelitis model [40].
Unless an agreement is reached and approved by Congress by the start of New Year's Day, more than $500 billion in 2013 tax increases will begin to take effect and $109 billion will be carved from defense and domestic programs.
As the abnormal metabolism of glucose and glutamine is the most studied alterations in cancer, inhibitors of glycolysis and glutaminolysis are in preclinical and clinical development yet none has reached an approved status.
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