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This suggests that the A63V+R193H combination may reach a functional threshold or a physiologic limit in which additional mutant incorporation no longer alters thin filament activation similar to previous reports where extracting only a fraction of troponin complexes (as little as 5%) results in nearly maximal Ca2+ independent thin filament activation [62].
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The model incorporates functional ceiling effects obtained by combining two strong activator alleles (or two strong deactivating alleles) where the myofilament activation (or deactivaiton) reaches a functional threshold and is no longer additive on a one to one basis.
If the concentration of any key protein has not reached a functional threshold in time, then this technique cannot be expected to fully rescue cybrid incompatibilities.
"You won't get taxed until you reach a certain threshold".
When these molecules reach a critical threshold concentration, a signal transduction cascade is triggered.
This pattern represents a scenario in which the phosphorylation sites accumulate to reach a predetermined threshold.
Progerin therefore must reach a certain threshold to induce DNA damage and inhibit proliferation.
Tonic immobility appears to be triggered when these sensory inputs reach a critical threshold.
Total protein translation must reach a critical threshold level before cell replication is allowed to occur.
After a time, the anatomical and functional magnitude of the lesions reach a threshold, and the symptoms [primarily dyspnea] become visible.
(2) Premature responses occur when firing rates reach a threshold, and ramping activity has a steeper gradient until that threshold is reached than on correct trials.
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CEO of Professional Science Editing for Scientists @ prosciediting.com