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The effect of oxygen (re-oxygenation) on cellular apoptosis was then analyzed in several cell lines with p53 and status.
Antioxidants increased further at LOE. Rate of oxygen increase during re-oxygenation did not affect antioxidant responses.
In rat hippocampal slices, oxygen plus glucose deprivation followed by re-oxygenation (OGD/Reox) elicited 42% cell death.
Toxic oxygen radicals are increased in hyperoxaemia [ 13] and in re-oxygenation after hypoxaemia.
Re-oxygenation upon return to normoxia may lead to the production of harmful reactive oxygen species (ROS), and it has been proposed that these animals need to repair tissues that might become damaged during re-oxygenation (Bickler and Buck, 2007).
In summary, C. abramoides incurred oxidative damage during hypoxic exposure with no additional damage inflicted during re-oxygenation: the rate of re-oxygenation was inconsequential.
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An hypoxia/re-oxygenation experiment using wild-caught Cyphocharax abramoides (Rio Negro, Brazil), was designed to answer these questions.
Hypoxia/re-oxygenation-induced ependymoglia activation and neurogenesis.
Hypoxia/re-oxygenation-induced neuronal cell death and microglia response.
Suppression of microglia activation does not inhibit hypoxia/re-oxygenation-induced ependymoglia proliferation.
(C ) Quantification of NeuN+/TUNEL+ cells after hypoxia and hypoxia/re-oxygenation. n = 4, *p < 0.05.
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