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During the course of these RCTs it is common for clinical exigencies to emerge that require rapid, direct intervention.
Although the review by de Souza et al. [53] includes three RCTs, it does not provide conclusive indications about the local drug infiltration in the osteoarthritic TMJD.
Although the efficacy of amitriptyline in pediatric migraine has never been assessed in RCTs, it remains one of the most widely used agents.
We continue to study new techniques, but with the results of last RCTs it is not reasonable to use them in routine practice or outside research protocols.
This review is limited to unravelling these from the RCTs; it is thus a hypothesis generating exercise.
Based solely on evidence from the three RCTs it would be difficult to recommend a policy of promoting circumcision.
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In the other RCT, it is clear that common ICU infections are excluded [41, 42, 45], namely caused by Pseudomonas aeruginosa Acinetobacter baumannii, as well as frequent clinical situations, namely endocarditis or infections that require long-course antibiotics and immunosuppressed patients.
While this may have influenced the findings in the RCT, it does not appear to have relevantly influenced the findings overall but probably adds to the overall heterogeneity as well.
During recruitment for the RCT it was decided to add a fourth non-randomized group.
We excluded Gärden 2013 because it was not a RCT; it used an historical control group as comparator (Gärden 2013).
Even though authors themselves may not proceed to a larger RCT it is possible that others reading the paper will.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com