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To study the expression of ADAMTs-5 and TIMP-3 in temporomandibular joint osteoarthritis (TMJOA) model rats, to explore and confer the possible effects of ADAMTs-5 and TIMP-3 involved in the degradation of the early stage of OA.
We plan to change the dosage and frequency of IS and use different sexes of rats to explore the aetiology of this comorbidity.
This study used hippocampal slices from pilocarpine-treated rats to explore the dependence of synaptic transmission in this pathway on stimulus frequency.
Continuing this line of investigation, two subsequent studies by the same group used relatively similar NaHCO3 dosing and high-intensity training protocols on rats to explore fibre-type dependent protein expression associated with H+ removal during rest and exercise [90, 91].
13550_2014_64_MOESM1_ESM.docx Additional file 1 Supplementary material to the manuscript by Tóth et al. Additional PET experiment using P-gp knockout and wild-type rats to explore the contribution of the ABC transporter P-gp on the brain uptake of [11C]AZ10419369.
The test relies on an innate tendency of rats to explore a novel environment [ 48].
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The novel object recognition test measures the natural propensity of a rat to explore a novel versus familiar object.
Each object was concurrently available for the rat to explore for a total of 1 min (Table 1A).
We performed multiple sequence alignment of Nrf2 and Nfkb1 genes in five mammalian species – human, chimpanzee, dog, mouse and rat – to explore conserved biological features.
For every trial, the rat was allowed to forage throughout the whole environment for 15 min. Cooked rice grains were scattered throughout the trial so as to motivate the rat to explore every region of the environment evenly and without depleting any of the compartments.
Each object was concurrently available for the rat to explore for a total of 1 min. The central sliding door was then raised to reveal two more objects (the now familiar object B2 vs. novel object C1) at the opposite end of the maze for exploration by the rat (Trial 2).
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