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Dahl salt-sensitive rats, models of salt-induced hypertension, excrete protein-bound vitamin D metabolites into urine, a process that is accelerated during high salt intake.
Compound 11e showed excellent efficacy for lowering glucose, triglycerides, body fat, in well established mice and rats models of diabetes and obesity and had a favorable ADME profile.
Details of the problematic issues in cancer drug discovery and screening methods using experimental mice or rats models of site-specific tumors have been recently reported [22, 44, 115 121].
These studies were all conducted in rats models of pathological trabecular bone quality at the time of PTH administration the initial low bone density inherent in these models gave room to bone improvement (Ohkawa et al. 2003, 2008).
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Rat models of S. epidermidis osteomyelitis are less common [41].
We re-explored these routes in rat models of hypoxemia.
In spite of the potential advantages of rat models of human disease, few actually exist.
Interestingly, ACE2 is markedly reduced in rat models of hypertension [56].
Such cytoplasmic aggregations were observed in rotenone rat models of PD [22], [27].
& Zucc using rat models of ethanol-induced ulcers and toxicity.
Currently, three rat models of HCC have been reported.
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