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The experimental model of uremia in anephric rats described here may also be appropriate for evaluation of new biocompatible dialysis solution.
Female Wistar rats were used for the experiments described here.
The experiments described here were performed in anaesthetised rats as the blink reflex is preserved under anaesthesia in humans and animals.
Forty adult male Wistar rats (250 400 g) were used for the experiments described here.
A total of 111 animals (106 rats, 5 mice) were used in the experiments described here.
Overall, the course of the focal neocortical epilepsy induced in the TeT/CoCl2 model described here resembles that seen earlier in cobalt-treated rats [ 3– 7, 10– 13].
Taken together, the small RNA compendium described here advances the annotation of small RNAs in the rat genome.
The method described here was adopted from a published procedure of O'Brien for mice and rats (16).
All the rats had previously served in a Skinner-box experiment, but were naive to the apparatus and stimuli described here.
The complete MP data described here has therefore also been used for building the new genome reference of the rat (Rnor5.0, GenBank ID GCA_000001895.3, unpublished results).
The effects described here have potential implications for the design and interpretation of biomedical studies of immune parameters in laboratory rats.
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