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Spinally applied TROX-1 dose dependently inhibited mechanically evoked neuronal responses in SNL but not sham-operated rats, consistent with behavioral observations.
Striatal expression of vesicular monoamine transporter and D1 receptor proteins were increased in post-hypoxic rats, consistent with depressed dopaminergic signaling.
Quantitative analysis of a series of sections in the rostral dorsal hippocampus showed increases in the CA3a′ area in MEMRI of trained Wistar rats consistent with the increased SO + SP area seen in the Timm's staining.
Insulin measurements revealed that obese ZDF rats had markedly elevated insulin levels compared to Lean rats, consistent with an insulin resistant phenotype (Figure 5B).
Small but statistically significant increases were confirmed for cholinergic (chrm2, chrna7) and serotonergic receptors (Htr1a, Htr2a) in FSL rats consistent with known neurochemical changes in the model.
The results of this study reveal an increased susceptibility to hypoxia in LCR rats consistent with the finding that risk factors for cardiac disease and, specifically, deficiencies in cardiac calcium homeostasis segregate with aerobic running capacity.
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The Mup cluster in these species, as defined by the interval between neighboring genes, is 12 18 times smaller than mouse and 6 10 times smaller than rat, consistent with expansions in rodents (Table 2).
Cardiac function improved in every drug-treated rat, consistent with marked trientine-evoked improvement in cardiac performance in rats with established heart failure caused by diabetic cardiomyopathy.
Our finding revealed a significant effect of smoking characteristic on BMD of lumbar spine and femur in rat, consistent with the results from previous studies[ 26, 27].
The lower hippocampal 5-HT turnover in F344 rats as compared to BN rats was consistent with the finding that F344 rats exhibited less anxiety (i.e., they showed more open arm exploration) than BN rats.
Our observation that endotoxemia resulted in an increased NOx accumulation in the myocardium of young rats and of senescent rats is consistent with these findings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com