"In my opinion, we need to take a step back and assess the situation rationally, focusing our energy on working out the root cause of this issue and finding solutions that will actually make a difference instead of jumping straight into the protesting".
In this article, with the application of selection criteria for both Leishmania major targets (e.g. in silico gene lethality) and drugs (e.g. toxicity), a method (MetDP) to rationally focus on a subset of low-toxic Food and Drug Administration (FDA -approved drugs is introduced.
Both sectors are rational actors: politicians seek re-election and so, rationally, they focus through that prism, while the private sector views things through its rational lens of economic gain and loss.
Thus, the chemical synthesis of peptides allows for a rationally designed vaccine to elicit a focused immune response.
Attempts to rationally redesign gates typically involve computer-assisted gate identification followed by modification using focused directed evolution.
Our experiments also focused on the understanding of the molecular function of HDAC8 in neuroblastoma to find rationally targeted treatment combinations for clinical application of HDAC8-selective inhibitors.
Because most anxiety is focused on the future, try to catch yourself having negative thoughts and think about them rationally, says Lauren Rose, a psychotherapist and founder of the Rose Center for Mind and Body in Rye, N.Y.
A focused combinatorial library of 126 mimetics of the RGD sequence based on sugar scaffolds have been rationally constructed using molecular modeling, with a particular emphasis on the stereodiversity of the library.
We have focused our efforts in studying the mechanisms underlying metastasis in pancreatic adenocarcinoma, with the goal of rationally identifying molecular targets that can be exploited to inhibit this process.
More recently, research has focused on identifying the intracellular effectors of these signaling cascades in the hope that more selective drugs may be rationally designed for therapeutic intervention.
