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The phrase 'rationally designed' is correct and usable in written English.
You can use it to describe something that has been thoughtfully planned and structured, usually with particular goals in mind. For example, "This course was rationally designed to provide students with the most comprehensive education possible."
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Though the potion is rationally designed, its ingredients sound like a witch's brew.
Herceptin, one of the first rationally designed cancer drugs to reach the market, is useful in certain cases of breast cancer but is no panacea.
The outcome would be a kind of inquiry rationally designed and devoted to helping humanity tackle problems of climate change and other global problems effectively, intelligently and humanely.
Suvorexant, which Merck describes as "rationally designed" — rather than stumbled upon, like most drugs — influences a more precise set of neurotransmitters and receptors.
But let's indulge the hopefulness for a moment and assume that we really are entering a golden age of rationally designed, targeted drugs.
Herein, 3D hierarchical Co Al-LDHs were fabriCo Al-LDHs rationally designed reaction system.
The peptide system VPE-VPK is a rationally designed heterodimeric coiled coil structure [1, 2].
Rationally designed RNA assemblies can thus be used to construct functional architectures in vivo.
Simultaneously, there is a growing literature describing rationally designed vaccines that induce protective conventional Abs.
The system is rationally designed to show life-like properties.
A rationally designed HIV-1 envelope protein antigen helps to initiate the production of broadly neutralizing antibodies in mice.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com