In an attempt to rationalize selection of promising therapeutic targets, metrics to evaluate 'translatability' have been developed [ 5, 6] and retrospectively validated [ 7].
In order to "rationalize" selection step, we took into account the importance of avoiding antigens that can potentially cause autoimmunity in man [ 13].
'Rational selection' proposes to rationalize therapeutic choices.
Posttraumatic sympathetic dystrophy, postmastectomy pain, postherpetic neuralgia, some forms of cancer pain, and other variants of neuropathic pain syndromes maybe addressed with novel adjuvant treatment protocols, planned on our cell-based TRPV1 assays, which may help to select among a number of empirically employed drugs (30+) and rationalize adjuvants' selection.
Equation (22) has a format similar to that of (11) to make it easier to rationalize the selection of kpE.
These findings are shown to provide key mechanistic insight and help rationalize the selection of the externally applied electric potential in order to enhance the SAM adsorption process.
In theory, radiobiological modeling, coupled with reliable predictive assays, can be used to rationalize the selection of patients for particular schedules in trials.
These findings uncover hCNT1 as a putative determinant for nucleoside analog chemoresistance in ovarian cancer and may help rationalize drug selection and delivery strategies for various histological subtypes of ovarian cancer.
The system is validated by a suitable set of constraints on selection functions, and these constraints can be rationalized under either interpretation of the selection function.
To illustrate a possible application of the developed tool, we have used it for rationalizing a bait selection strategy for a large-scale protein complex pull-down experiment.
