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This study constitutes the first step towards a rationalized design of future new antimalarial agents targeting PfCCT.
The proposed modeling, findings, and discussions provide the basis for policy instruments and will be useful for the enhanced planning of on-site movement, improved regulation of tourist flows, and rationalized design and management of tourist destinations.
Therefore, our data reveal a role for HDAC4 in regulating cellular energy output and as such provide insights into rationalized design of novel anti-diabetic therapeutics.
A Cu-SAPO-34 material with very high activity for selective catalytic reduction (SCR) of NOx and hydrothermal stability has been synthesized following a sequential rationalized design.
A rationalized design is the output of a possibly very complicated nonlinear optimization, and it is very hard to make changes to such a highly constrained geometric model.
Because these moieties interact ubiquitously with various biological materials, particularly proteins, there needs to be a rationalized design of surface ligands.
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As various components of the endocannabinoid system have become therapeutic targets, understanding the endocannabinoids' mechanism of action is an important research topic for a rationalized drug design and optimal therapeutic strategies.
Discerning different components that contribute toward a favorable protein– ligand interaction could contribute significantly toward better understanding protein function, rationalizing drug design and obtaining design principles for protein engineering.
These biokinetic coefficients yield a set of realistic design parameters, which can be used in rationalizing the design of the activated sludge process for a specific substrate.
In order to rationalize the design of such new materials structural information about the film is needed.
Density functional theory (DFT) calculations of RC2P-RC4P were carried out to rationalize the design.
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CEO of Professional Science Editing for Scientists @ prosciediting.com