Our results have extended our previous observations of the importance of type II RTKs in gefitinib resistance and support the rationale of combination strategies that target the InsR-A or IGF-1R in concert with the EGFR for maximum antitumour effects.
It is known that proteasome inhibition prevents degradation of Pim kinases, lending rationale to combination of Pim inhibitors with proteasome inhibitors, a key standard component of MM treatment regimens.
The possibility of induced resistance again highlights the likely benefit from relatively aggressive treatment regimes and provides the rationale for combination of ADI-PEG20 with other therapies with distinct mechanisms of action.
The rationale for combination of SIFT and cLBP is that at pixel level, the oriented gradient has been assigned to 8 bins in SIFT, while in uniform LB P 8 2, 1 the number of bins is 59.
Accumulated evidence points to the rationale for combination of molecule-targeted therapies to delay or overcome the acquired treatment resistance.
This feature may set a rationale for combination treatment of PIs with anti-CD20/rituximab [ 48].
Development of these agents has improved the treatment of advanced melanoma, and their diverse mechanisms of action support the rationale for combination regimens.
On the other hand, the rationale for combination therapy is inhibition of either a single pathway (vertical blockade) or different pathways (horizontal blockade) in order to increase efficacy and reduce toxicity [ 7].
These data support the rationale of the combination therapy to produce greater weight loss at lower doses than the individual components when used alone.
The rationale of the combination of 5-FU with CI and GEM is to prolong thymidylate synthetase inhibition, increasing the chance of pharmacodynamic with GEM and to reduce toxicity with respect to 5-FU bolus.
The rationale of this combination is based on preclinical studies describing a synergistic effect on xenografts models of human glioma and paediatric solid tumours (Houghton et al, 2000; Patel et al, 2000).
