Collectively, our data provide a strong rationale for further study into mechanisms of phospho-PR-dependent regulation of transcription and the potential contribution of this activity to early or rapid breast cancer progression towards endocrine resistance.
Our meta-analysis, however, strengthens the rationale for further study of high dose negative ionization (>2.7 × 10 ions/cm) on depression severity, an effect, if real, that remains to be fundamentally understood.
The observation that plasma proteins present in the OA joint can stimulate macrophages provides important rationale for further study of this pathway in OA models, but also may implicate this pathway in a variety of other local joint conditions that may produce alterations in synovial diffusion properties.
Our result that both UFH and low molecular weight heparins inhibited permeability increases induced by HBP suggests a cogent rationale for further studies of heparin(s) to prevent sepsis-induced ARDS and vascular leak.
While mindful of some of the limitations of this study, we believe that our findings provide a fundamental rationale for further studies using select probiotic microbes in an overweight setting.
Together, these observations point to an essential role of APP intracellular domain for normal APP processing and function in vivo, and provide rationale for further studies into physiological functions associated with this important phosphorylation site.
The current results, however, provide a convincing rationale for further studies to investigate SPRED2 as a candidate tumour suppressor in prostate cancer.
These data provide a rationale for further studies investigating CCR7 and the regulation of Treg trafficking as potential therapeutic targets against IPF.
While proving pathogenicity is beyond the scope of this study, our analysis may serve as a sentinel for novel organisms with pathogenic potential and provide a rationale for further studies to define their pathogenicity.
While the small study size and lack of a placebo control prevents these data from bearing any significance clinically, it does provide a rationale for further studies on using memantine as a therapy in patients with PTSD.
