(Similarly, Snowden's revelations demonstrated how the government was using legal rationale derived from a case involving old telephone-switch-box technology as justification for collecting cell-phone metadata).
These compounds were identified with receptor-based virtual screening and then chemically optimized on the base of rationale derived from biochemical screening and molecular modeling.
However, the development of the interventions primarily built on a theoretical rationale derived from efficacy studies.
This approach has an interesting preclinical rationale derived from studies that have suggested the power to increase tumor growth following withdrawal of VEGF inhibitors.
Moreover, if the IATA is based on mechanistic rationale, derived, for example, from knowledge described as an AOP, then the value of the method will be related to its (mechanistic) relevance to key events and the reliability (reproducibility) of the data it generates.
These rationales were derived from several group sessions with attending and housestaff physicians where clinical management strategies were discussed.
This rationale is derived from human capital theory, which focuses on the economic productivity of individuals over time, and the conditions which enhance it.
Most resources advise caution in interpreting these investigations, noting their exploratory nature, but when there is a clearly stated rationale, especially when derived from previous research, and sufficient trials are included, a priori planned investigations may improve applicability.
The interaction in our haptic display occurs through a single haptic port under the rationale that assessment techniques derived from the use of this tool should be directly applicable to both on-site and remote scenarios (Figure 1).
The rationale for this approach is derived from preclinical work demonstrating dual apoptotic signaling, with in vitro modeling suggesting the synergistic tumoricidal activity of bortezomib and lenalidomide.
