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Their main tactical approach is to design an intervention based upon sound rationale (whether medical, scientific, or social), test it in a real situation, measure and modify it, then continue until the implementation is optimized.
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The key challenge for practitioners is not simply to base their work on theory (they always work from implicit assumptions and rationales, whether or not they do so consciously), but to make explicit the informal and formal theories they are actually using.
We also collected information on whether a systematic review had been conducted to support the trial rationale and whether a systematic review was cited in the trial report.
Intervention Rationale assesses whether a rationale was given that suggests why the intervention may produce improvements in the outcome (empirical evidence, theories or logic models).
The statistical effect model planned a priori was reported in most reviews; however, reviewers either chose a fixed effect model (64%) or reported neither fixed nor random models without adequate explanation of the rationale and whether their choice would be altered by the subsequent heterogeneity assessment of the included studies[ 17].
For reoptimization, the rationale behind is whether there is any possibility to answer a TSP query based on an indexing to maintain certain length optimal circuit, even though it is known that the local optimal property does not hold.
"What I'm waiting for is some rationale as to whether she's truly interested in keeping fossil fuels in the ground in a consistent fashion or whether she's just piecemealing the Arctic from a old-school environmentalist point of view," Miller told VICE News.
Nevertheless, our data showing that miR132 markedly affects MeCP2 expression in vivo, provide a strong rationale for examining whether dysregulation of miR132 could be contributing to Rett Syndrome and other MeCP2-related disorders.
Our data thus provide a rationale for testing whether hydroxyurea and other HbF-inducing agents can be used as prophylaxis against severe and fatal malaria in very young 'wildtype' children who lack protective polymorphisms.
Based on this rationale we assessed whether homoarginine deficiency is a risk factor for SCD in dialysis patients.
We therefore used this rationale to test whether identifying coevolving pairs of sites could allow us to identify known functionally important domains due to their three-dimensional proximity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com