The one- and two-year clinical trials for a recently approved anti-obesity drug (phentermine/topiramate ER) provide no rationale for weight regain with on-going use of the medication, however, estimating some degree of weight regain provides a lower bound for cost savings.
Also, the rationale for weighting or excluding studies based on quality appraisal should be explicit.
Considering electricity, refrigerator and radio, the rationale for weighting was that respondents cannot have a refrigerator if they do not have electricity.
If the frailty index were meant to be a mortality prediction instrument, there might be a rationale for weighting several items, particularly age [ 26].
A second aim is to consider the conceptual homogeneity of the GRADE criteria, the rationale for weighting the GRADE criteria, and the rationale for summarizing the values decided for each criterion in order to reach the overall rating of confidence in the effect estimate.
Although this is easily achieved in a practical sense, the biological rationale for weighting morphological variation over neutral molecular variation (or vice versa), or within population variation over among population variation (or vice versa) is not obvious and a consensus would likely be difficult to reach (e.g., Petit et al. 1998).
Given the increasing use of composites, research is needed to define which indicators can legitimately be made into composites, to develop and test clear rationales for weighting schemes, and to build understanding of how changing weights alters conclusions about performance [ 41].
But the Postal Service rationale carries little weight with Ms. Frankel.
In addition, the results inform public health policy, demonstrating further rationale for preventing weight gain and delaying the onset of obesity.
The rationale for adult weight management in Dutch primary healthcare is based on the health risks associated with overweight and obesity.
