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These data support the rationale to validate prospectively the influence of primary tumor resection on bevacizumab antitumor effect in synchronous mCRC.
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These data support the rationale to prospectively validate the influence of primary tumor resection on bevacizumab efficacy in synchronous stage IV colorectal cancer.
Yes, questions will be raised about the researchers' findings, or about the Darwinian rationale that appears to validate them, but these and other details need not detain us.
We projected the development environment implementing this model as part of the European FP7 FAST Project, which was used to validate the rationale behind our approach.
No clinical studies were done to validate the rationale of UVR filtering, primarily because the UVR filtering could not negatively affect vision, since visible wavelengths remained unaffected by such filtering.
The rationale behind performing this comparison to validate and test the B. bronchiseptica long-oligonucleotide microarray is that this comparison will globally identify B. bronchiseptica genes regulated by BvgAS.
In addition, the effects on the community structure of the stool microbiota will be explored in a subset of patients to validate the mechanistic rationale underpinning the synbiotic therapy.
Finally, our combined in silico and in vitro data may serve as a good rationale for clinical researchers who wish to validate promising candidates for SNP markers.
Although a causal relationship could not be established due to the retrospective design, we believe that our results provide the rationale for a future randomized trial to validate this observation.
The effects observed in our cohort provide the rationale for larger studies in independent cohorts to validate the results presented here.
Taken together, all of the above provide a strong rationale to select HDAC6 as a primary candidate to validate our screen and further investigate its role in IBC cell survival.
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