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Tailings contained in a column with no horizontal discharge and homogeneous material properties provided the rationale to develop a one-dimensional model.
The clinical findings served as the rationale to develop a pre-clinical model of pevonedistat drug-induced toxicity.
This has provided the rationale to develop a robust health economic model that brings together the best available evidence for the efficacy and safety of different treatment options to estimate relevant overall health outcomes and costs.
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Hence, there is a rationale to develop an effective and well-tolerated platinum-based regimen for metastatic breast cancer (MBC).
While the rationale to develop such a population register is to improve population health and equity through systematic medical audit, appropriate safeguards should be in place to limit any unintended misuse of possible confidential health data.
Our data provide a rationale to develop combinations of mAbs for human H5N1 prophylaxis and therapeutics.
Our data provide a rationale to develop CRC therapy stratergies targeting the CaSR.
The fact that HDAC1 has been linked to regulation of cell growth and survival does not imply per se a rationale to develop subclass-specific inhibitors.
Recent molecular studies have advanced our understanding of the disease and provided a rationale to develop novel strategies for early detection, classification, prevention and treatment.
These unexpected results provided the first preclinical evidence of a method to specifically target cyclin D1b-expressing tumors and serve as the rationale to develop cyclin D1b expression as a novel biomarker of therapeutic response.
A stimulatory effect of chemotherapy on tumour immunogenicity without impairing immune effector cell function would provide a strong rationale to develop novel chemoimmunotherapeutic strategies.
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