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The structures allow a detailed rationale to be developed for the observed affinity of the PU3 class of compounds for HSP90 and also provide a structural framework for design of compounds with improved binding affinity and drug-like properties.
Scarecrow tries to reason with the birds by reading relevant quotations from figures such as Francis Bacon and Cicero as a rationale to be freed.
Nevertheless, we consider the rationale to be stronger for ROTEM ®-guided, concentrate-based therapy.
Specifically, saliva or buccal cells offer an easy, saving, inexpensive and non-invasive method with accumulating scientific rationale to be added in general population surveys.
The reviewers' question made us further realize that other labs facing a similar choice between inactivation techniques might find our rationale to be of interest.
This may perpetuate a perception that there is less need for the theoretical rationale to be reported in quantitative studies and may have been influential in this review predominantly including questionnaire-based and qualitative interview studies.
Similar(50)
Overall finds most of the other frequently invoked rationales to be, philosophically speaking, similarly inadequate.
The rationale seems to be: case closed, why bother investigating anything?
Without anality and sexual dysfunction, the rationale seems to be, how could you make them credible?
But the third rationale looks to be rock solid.
But I think the world is too plural for that rationale now to be very cogent.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com