Based on this rationale, CAR T cells can be engineered together with other immune modifiers, such as IL-2 and IL-18, or costimulatory ligands to shape the tumor environment (Chmielewski and Abken, 2015; Chmielewski et al., 2014).
The rationale for Ted Cruz was that he took on the bad guys in Washington.
Finally, the rationale behind T-score is described.
"From both a strategic and economic perspective, the rationale for the T-TIP could never be stronger," he said, referring to the proposed accord's official name, the Transatlantic Trade and Investment Partnership.
12 Based on the rationale that disease-relevant T cells may express a limited number of T-cell receptors (TCR) or skewed repertoire, 13– 15 the second approach used the TCR as a guide to identify relevant cells in brain tissue.
The model is based on the rationale that the alloreactive T cell repertoire is shaped by thymic selection, leading to central deletion of clones reactive to self-epitopes.
But the advisory firm questioned the rationale for joining with T-Mobile, which has struggled against bigger rivals like AT&T, which failed to buy the company for $39 billion two years ago, and Sprint Nextel.
The addition of pertuzumab fully restored the apoptotic response to T-DM1, providing additional evidence for the rationale of combining pertuzumab and T-DM1 [ 45].
These results provide further support for the rationale to use "direct" host T cell therapy for prolongation of allograft viability as an alternative to "indirect" therapy mediated by donor T cell infusion.
Our data suggest that the processes leading to alterations in immune tolerance may be caused or sustained by the genetic framework, and, hence, support the rationale for therapeutical approaches targeting T and B lymphocytes in autoimmune disorders.
