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Rationale: Studies showing renal and ear toxicity associated with aminoglycosides are old and based on a design of twice-daily administration without any consideration of residual serum concentration levels [140 142].
Rationale: Studies of outbreaks based on the phenotypic characteristics of microorganisms (antigenic properties, metabolic or antibiotic resistance) are limited and do not provide conclusive differences or similarities between them.
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This article reports the rationale, study design and analysis plan of the ANDROMEDA-SHOCK Study.
The rationale, study methods, and data on presenting populations are described.
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This paper presents the rationale, study design and protocol for an open label randomized controlled trial to improve parent-youth partnerships in self-management and medication adherence to HU in adolescents with SCD.
Details of the rationale, study design, and methods have previously been described (13).
Details of the rationale, study design, and methods have been described previously (10).
The rationale, study design, and entry criteria for the ACCORD trial are described elsewhere (8– 10).
Details of the rationale, study design, and methods have been described previously (6).
The rationale, study design, and baseline characteristics of the study have been reported in detail previously 20 and will be presented here briefly.
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