The perceived characteristics, mode of action, rationale, roles, and clinical outcomes explains why and how people use CAM and conventional medicine both in isolation and in combination.
However much it was believed, the king's divine status was the rationale for his role as Egypt's representative to the gods, as he formed a link between the divine and human realms.
Independently, there is strong scientific support and rationale for a role of perlecan in angiogenesis or neovascularization [ 17, 20, 21].
The participation of BRCA1 in DNA repair provides a strong rationale for a role of BRCA1 in the response to DNA-damaging drugs.
Recent studies provide both a pathogenetic and epidemiological rationale for a role of serum uric acid (SUA) in the development of diabetes (2, 3).
All variables planned for investigation must have a sufficient scientific rationale for their role as a treatment effect modifier [ 1, 7, 17, 20, 26, 27, 32- 37] 37],[ 38].
On the basis of the structure of the SMN Gemin2 interface, one rationale for a role of Asp interacting with Gemin2 is a potential electrostatic interaction with Arg that would be disrupted with the D44V substitution.
SAA and S100A14 have been implicated in inflammatory processes (e.g., Han et al. 2007) or inflammation-related diseases (Chen et al. 2009) and thus provide a rationale for a role in O3-induced inflammation.
Our aim is not primarily to identify which interventions are or should be implemented, but more importantly, to identify where rationale plays a role in implementing ASP interventions and what the consequences are for expert-based ASP strategies.
In spite of the strong rationale for a role of genetic variants in Osterix influencing bone mass acquisition, we are not aware of any previous genetic studies in humans highlighting this association.
Previous studies of β-catenin dependent mechanisms in immune tolerance provided the rationale for assessing the role of WNTs in IELs function.
