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The rationale supporting placebo surgery controlled design includes demonstrated considerable 'placebo effect' in surgical trials and optimal blinding of both the patient and the physician-researcher.
These experimental approaches provide strong rationale for placebo-controlled pharmacological trials to establish the efficacy of cilostazol in patients with AD/CAA.
[28] Our study suggests that openly described inert interventions when delivered with a plausible rationale can produce placebo responses reflecting symptomatic improvements without deception or concealment.
This paper presents the design and rationale for a randomised placebo controlled trial examining the effect of paracetamol on the recovery of patients with acute low back pain.
Our application to the Pirkanmaa Hospital District IRB contained a specific, six-point ethical analysis focusing on the methodological rationale for use of placebo surgery, risk-benefit assessment and informed consent as outlined by Miller (box 1).
That's the rationale behind research into placebo-controlled dose reduction.
To describe the study design and rationale for the first placebo-controlled, randomized clinical trial to be conducted by the Chronic Prostatitis Collaborative Research Network sponsored by the National Institutes of Health.
The rationale for pooling the placebo- and active-comparator patients was to provide greater power for this analysis by increasing the sample size and the number of observed outcomes.
Eighteen of the study protocols (35%) stated a rationale for the use of placebo.
Eighteen of the study protocols (35%) provided some rationale for the use of placebo.
In a large majority (77%) of the participant-information documents, no rationale for the use of placebo was presented.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com