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The rationale of this trial is based on the generally accepted finding that an improvement of pancreatic microcirculation prevents the progression from mild edematous to severe necrotizing pancreatitis [ 3- 7, 11].
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A review by O'Shaughnessy in this supplement provides the rationale for this trial and a description of its design.
This involved teaching on the processes and rationale of the trial as well as instruction on how to deliver exercise groups.
This pilot data will (1) inform the underlying rationale of the trial by producing evidence, if it exists, of relationships between objective measures of sitting and standing and body composition and (2) generate an effect size on which to base sample size calculations to inform the main trial.
The top three motives for recruiting patients were: (1) the attractive scientific rationale of the trial (84%); (2) a design that was easy to explain to patients (79%); and (3) a pragmatic trial design in line with standard practice (76%).
The rationale of the trial and its design have been described in detail elsewhere [ 18, 19].
The project coordinator telephoned the GPs as soon as a patient was assigned to intervention and explained the rationale of the trial.
17 These studies, therefore, support the rationale of the trial design reported here for attempting to deliver cell therapy as soon as possible after AMI.
This paper describes the rationale and protocol of this trial.
The purpose of this paper is to describe the rationale and design of this trial.
Publishing the design and rationale of this randomized controlled trial (RCT), including a cost-effectiveness analysis, before the results are available, has some important benefits.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com