As so often happens in medicine, many years were to pass before the rationale of liver therapy in pernicious anemia was fully understood.
Because the rationale of the therapy with platelet-derived compounds is still debated, a definitive insight can be acquired only when these large randomized trials will be completed.
Such studies show the rationale of applying therapy early on.
The rationale of adjuvant therapy is to reduce the rate of local relapse and distant metastasis.
The rationale of the therapy is that the strengthened external anal sphincter and pelvic floor muscles would support the rectum adequately causing amelioration of the rectal prolapse.
Based on the rationale of adjuvant therapy targeting low-volume disease and that serum CA19.9 is a measure of disease burden, CA19.9 may have predictive value in the adjuvant setting.
The rationale of vasodilator therapy is based on the concept that blood flow in the peripheral circulation is regulated by changes in perfusion pressure, which is determined by intravascular pressure gradient and vessel radius of arterial peripheral circulation.
The rationale of antiangiogenic therapy for solid tumors is founded on the fact that tumor growth and metastasis depend on the establishment of tumor vasculature, in which vascular endothelial growth factor (VEGF) signaling has been revealed to be one of the critical mechanisms [ 2, 5, 6].
In case the physiotherapist finds out that significant others, like partners or co-workers, influence the change in pain behaviour in a negative way, they are invited to attend one or more sessions to gain insight in the rationale of the therapy.
Moreover, our studies establish MEK inhibition as a candidate rationale for therapy of other pathological conditions not related to PD, such as post-operative adhesions, and other non-peritoneal fibrotic inflammatory diseases.
